Lactobacillus plantarum A3 attenuates ulcerative colitis by modulating gut microbiota and metabolism

Abstract Antibiotics are widely used to treat various diseases. However, growing evidence indicates that antibiotic therapy in human life increases the incidence of inflammatory bowel disease (IBD). Therefore, we need appropriate methods reduce or symptoms IBD. In this study, lincomycin hydrochloride construct a gut microbial dysbiosis model mice, and then, constructed an ulcerative colitis (UC) model. Meanwhile, Lactobacillus plantarum A3 from equine UC mice with dysbiosis. The results showed had little effect on small microbiota but more destructive large intestin. alleviated which was reflected its significantly reduced spleen index activity (DAI) ( p < 0.05), inhibited shortening colon invasion cells colon. Moreover, found it played mitigatory role by inhibiting oxidative stress regulating cytokines mice. At same time, restored diversity composition colonic increased abundance beneficial bacteria such as Blautia Akkermansia 0.05); Notably, concentrations arachidonoyl ethanolamide phosphate (AEA-P) cortisone 0.05) have analgesic anti-inflammatory effects. conclusion, our study has potential regulate